Journal: Nature Biomedical Engineering
Article Title: High-resolution prosthetic hearing with a soft auditory brainstem implant in macaques
doi: 10.1038/s41551-025-01378-9
Figure Lengend Snippet: a , Left: schematic of an NHP brain. The soft ABI is implanted on the cochlear nucleus; the soft ECoG records cortical responses from the auditory cortex. Right: NHP behavioural task in response to electrical or acoustic stimulation. Created with BioRender.com ( https://BioRender.com/y29o453 ) and using a brain image from Adobe Stock. b , Photograph of the integrated soft ABI and its connectors: an Omnetics connector is embedded in a PEEK pedestal and connected to the soft ABI. An imaging marker and resorbable insertion spine are also visible. c , Integrated soft ECoG device: 29 electrodes (300-µm diameter) that record cortical signals. d , Close-up of the soft ABI: 11 electrodes (100-µm diameter). Right inset: FlexComb connector . e , f , In vitro characterization of the soft ABI ( e ) and EcoG ( f ). Left: EIS measurement, where data points represent the average and bars represent standard errors for all electrodes. Right: VT in response to a 100-µA biphasic current pulse. The thick blue line represents the average and light lines represent individual electrodes. g , Scanning electron microscopy (SEM) images of micropatterned ABI electrodes and interconnects. Top left: image of one ABI electrode and associated interconnect. Red frame, close-up of an interconnect; green frame, close-up of the electrode. Bottom right: colourized SEM of the electrode and encapsulation of the platinum layer within the polyimide dielectric layers.
Article Snippet: The ECoG platinum ground wire (PFA-coated platinum wire (127 μm bare diameter); A-M Systems, 773000) with exposed tip was placed epidurally and below the skull in the frontal part of the craniotomy.
Techniques: Imaging, Marker, In Vitro, Electron Microscopy, Encapsulation
